For every path you choose, there is another you must abandon, usually forever.
Throughout the ages, stories with certain basic themes have recurred over and over, in widely disparate cultures; emerging like the goddess Venus from the sea of our unconscious.
Humans are upsetting a fragile balance that their own human ancestors established.
These days too many of us seem inclined to cover our ears, close our eyes, and blindly follow the most narrow, conservative tenets of religion; or else seek comfort in the ancient traditions of New Age ritual.
Studying anthropology, I developed a kind of holistic view of human existence, in which the dichotomies you listed are all necessary and vital aspects of life.
We are all born with a unique genetic blueprint, which lays out the basic characteristics of our personality as well as our physical health and appearance... And yet, we all know that life experiences do change us.
Besides, wouldn't it be wonderful if no one ever had to worry about the random cruelty of fatal illness or the woes of old age attacking them or their loved ones?