My interest in protein breakdown as a research problem began in l955 at about the time I joined the Biochemistry Department of Yale University. It was known that proteins break down intracellularly in the mature animal.
My Ph.D. thesis problem was to determine if the DNA content of rat tissues increased if there was B12 in the diet. This problem was suggested by my adviser based on the observation that thymine could replace vitamin B12 in a lactobacillus.
We moved from the East coast to the town of Spokane, Washington, when I was about 13 years old, and I did not adapt very well to the, to the style of the place, and I spent most of my time in the public library.